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Alzheimer’s disease is a progressive, neurodegenerative disease characterised by a gradual but profound decline in cognitive abilities and the appearance of β-amyloid and tau aggregates (plaques and tangles) in the brain. Because the loss of memory is the most common symptom lamented by affected patients, the disease is often regarded simply as a memory disorder.  In the majority of individuals with Alzheimer's Disease, however, multiple cognitive domains are compromised including attention and response control; indeed such impairments can occur early in the disease and precede language and spatial impairments. Our work in this area mainly involves developing and validating assays for phenotyping murine models of this disease across all of these domains of cognition.

We are members of a large, interdisciplinary Alzheimer's Disease Consortium, funded by the MRC/Wellcome Trust Neurodegenerative Diseases Initiative. The consortium includes groups from Cambridge, Bristol, Hamburg and Toronto and integrates tools from physics, chemistry, engineering, systems biology and neurobiology with the overarching goal of understanding how the accumulation of tau and β-amyloid proteins results in the death of brain cells.

Dr Pedro  Bekinschtein
I'm interested in the neurobiological mechanisms involved in pattern separation, the computational process by which the brain makes similar representations of events more dissimilar or less confusable. I use a combination of pharmacology, brain stainings
Professor Tim  Bussey
Professor of Behavioural Neuroscience
Fellow of Pembroke College
+44 (0)1223 333585
Dr Chris  Heath
I am interested in understanding how pathology-related molecular and cellular changes in defined neuronal circuits affect behaviour and cognition in Alzheimer's Disease.
Dr Alexa  Horner
Cognitive characterisation of genetic models of neurodegenerative and neuropsychiatric diseases which affect cognition, using a battery of touchscreen tests.
 Brianne  Kent
The role of plasticity-related mechanisms in the perirhinal cortex and hippocampus during pattern separation.
Dr Chi Hun  Kim
Screening and translation of novel therapeutics from the bench to dementia patients using cognitive tasks optimised for use in both disease models and humans.
Professor Lisa  Saksida
Professor of Cognitive Neuroscience
Fellow of Newnham College
+44 (0)1223 765207