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Translational Cognitive Neuroscience Lab

 

Tue 11 Jun 09:30: Child Development Forum Easter II

Neuroscience Talks in Cambridge - Sun, 14/04/2024 - 11:20
Child Development Forum Easter II

Speakers TBA

Child Development Forum are a series of talks bringing together researchers of infant, child and adolescent development across the University of Cambridge.

Talks are termly, and usually held at the MRC Cognition and Brain Sciences Unit (Chaucer Road).

Join the mailing list to kept up-to-date, and sign up to give a talk:

https://lists.cam.ac.uk/sympa/info/ucam-childdevforum

This talk is part of the Child Development Forum (CDF) series.

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Thu 09 May 16:00: Behavioural and mechanical heterogeneities underpin cell migration essential for mouse anterior patterning

Neuroscience Talks in Cambridge - Fri, 12/04/2024 - 09:03
Behavioural and mechanical heterogeneities underpin cell migration essential for mouse anterior patterning

Abstract not available

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Fri 17 May 16:30: The Cognitive Biology of Language The host for this talk is Jeff Dalley

Neuroscience Talks in Cambridge - Thu, 11/04/2024 - 15:21
The Cognitive Biology of Language

The cognitive revolution in the middle of the last century has transformed the ways in which we study the human mind. Curiously, when it comes to language there is a growing behaviourist trend, where it is regarded as an acquired skill, not unlike the way in which Large Language Models (LLMs) work. In contrast, linguists in the Generative Grammar tradition consider the faculty of language to be a computational system within the mind, part of the human biological endowment. This means that biological aspects of language, in particular evolution, development, and (neural) mechanisms, are open to investigation. I will discuss recent work on ‘comparative linguistics’, particularly the behavioural, neural and cognitive parallels between human language and birdsong, and what we can and cannot conclude from it. The current behaviourist view of language has led to the rapid rise of LLMs, although these AI models are actually not about language at all. Natural language appears to be unique to the human mind, and has no parallels either in animal or artificial intelligence.

The host for this talk is Jeff Dalley

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Wed 24 Apr 15:00: Social and political change in diverse societies: Insights from largescale panel studies

Neuroscience Talks in Cambridge - Wed, 10/04/2024 - 15:19
Social and political change in diverse societies: Insights from largescale panel studies

Largescale panel studies, with stratified, random samples of a nation’s population, are relatively rare in the psychological literature. By measuring change at multiple levels over long periods of time, these studies can tell us about the relationship between individuals and the societies in which they live. This includes (1) how features of the social structure, such as inequality or deprivation, affect people and (2) how people affect the social structure (via their policy preferences and political behaviour). I will review recent research on these two key elements of societal functioning – structural effects and structural change – from two panels in very different contexts. The first is a 13-wave longitudinal study of around 20,000 New Zealanders. The second is a 3-wave study of around 160,000 people in India. I will also introduce a new panel from the UK, where we invite 500,000 people randomly sampled from the electoral register to participate in survey of social and political attitudes annually over five years. This research programme demonstrates how largescale panel data can inform theory and policy, by telling us more about how people change, and how they change their societies.

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Wed 17 Apr 11:30: Sex differences in co-occurring conditions among autistic individuals

Neuroscience Talks in Cambridge - Tue, 19/03/2024 - 09:01
Sex differences in co-occurring conditions among autistic individuals

Co-occurring conditions, both psychiatric and somatic, substantially impact autistic individuals’ quality of life. Understanding the association between autism and co-occurring conditions and identifying factors that influence this association is a leading priority for autistic individuals. Across different cohort studies we explored the association between sex and co-occurring conditions using Swedish nationwide register data. We investigated sex differences in psychiatric diagnoses preceding a diagnosis of autism, their association with age at autism diagnosis and their stability post autism diagnosis. Moreover, we examined mental health problems and psychiatric hospitalization in autistic females and males aged 16 to 25 compared to nonautistic individuals. Lastly, we explored how somatic conditions in childhood (SCCs) are associated with psychiatric conditions in young adulthood (PCAs), and how psychiatric conditions in childhood (PCCs) are associated with somatic conditions in young adulthood (SCAs). I will make the case that autistic people, especially women, have considerable mental health needs.

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Wed 20 Mar 16:00: Political Polarization, Social Norms, and Sorting: An Agent-based Social Sampling Model In person only

Neuroscience Talks in Cambridge - Mon, 18/03/2024 - 10:18
Political Polarization, Social Norms, and Sorting: An Agent-based Social Sampling Model

I will describe a cognitive model of social influence and apply it to several social network phenomena including polarization, social contagion, and sorting/issue alignment. We use agent-based modelling to link individual-level and network-level effects. Social norms and individuals’ private attitudes are assumed to be represented as distributions rather than single points. People located within a social network observe the behaviour of their network neighbours and hence infer the social distribution of particular attitudes and behaviours. It is assumed that (a) people dislike behaving in ways that are extreme within their neighbourhood social norm (social extremeness aversion assumption), and hence tend to conform and (b) people prefer to behave consistently with their own underlying attitudes (authenticity preference assumption) hence minimizing dissonance. Expressed attitudes and behaviour reflect a utility-maximizing compromise between these opposing principles. A number of polarisation-related social network phenomena emerge in the model. Sorting (increased correlation of attitudes) is shown to emerge only when agents seek to differentiate themselves from an outgroup as well as align with an ingroup.

This talk is in person only and hosted by David Young and Lee De-Wit.

In person only

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Wed 20 Mar 11:30: From precision medicine for autism to precision support for neurodivergent people: Why we need to consider dynamic interactions between brain, body and the social environment to better understand each other.

Neuroscience Talks in Cambridge - Fri, 15/03/2024 - 17:18
From precision medicine for autism to precision support for neurodivergent people: Why we need to consider dynamic interactions between brain, body and the social environment to better understand each other.

Over the past decade, two approaches have substantially influenced the direction of autism research: precision medicine in psychiatry and the neurodiversity paradigm. Precision medicine aims to improve early detection, diagnosis and prognosis, as well as develop mechanism-based therapies tailored to individual needs/ characteristics using biomarkers. EU-AIMS and AIMS -2-TRIALS are two linked European consortia that have been at the forefront of this global effort. In this talk, I will share some reflections on progress and challenges. Significant advancements include larger, comprehensively characterised cohorts from infancy to adulthood, new methods to make predictions about individuals and identify subgroups and increased methodological rigour. However, in our studies, we did not identify single modality markers that have sufficient accuracy for any clinical application. This may be due to both methodological factors, including granularity and reliability of measures, and conceptual factors, such as the predominant reductionist approach, which seeks to parse complex issues into simpler, more tractable units. By studying particular processes in isolation (e.g., social or sensory processes) we often neglect their interactions, while the focus on individual-level markers has led us to divorce the (autistic) person from their social environment.

In parallel, the neurodiversity paradigm has highlighted the need to shift away from deficit models to understanding diversity in perception, cognition and experiences. It emphasised the role of social and contextual factors in strengths and disabilities and advocated for active involvement of autistic people as research collaborators in defining priorities and conduct of research.

Drawing upon insights from system biology, developmental psychology and social sciences I outline an integrative approach. It aims to understand the dynamic interaction between biological (brain, body) and social mechanisms (stress, stigma, protective factors) to gain a fuller understanding of strengths and difficulties of neurodivergent people in different conditions and contexts.

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Tue 19 Mar 10:00: Neurotransmitter receptor gradients: gateways for subcortical routing of cortex-wide dynamics during cognition

Neuroscience Talks in Cambridge - Fri, 15/03/2024 - 14:52
Neurotransmitter receptor gradients: gateways for subcortical routing of cortex-wide dynamics during cognition

Recent advances in connectomics and neurophysiology make it possible to probe whole-brain mechanisms of cognition and behavior. However, as yet, few models in computational neuroscience have tackled the mechanisms underlying highly distributed neural activity during cognition. In this talk I will describe our anatomy-led approach to developing cortex-wide models of neural dynamics during cognitive tasks and our recent anatomical findings of graded expression of neurotransmitter receptors in the cortex. I will highlight our investigations into how inputs from the thalamus and neuromodulatory systems may shift the cortical dynamical landscape, and how this may confer flexibility on distributed cognitive functions such as conscious perception and working memory.

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Cambridge Memory Meeting 2015

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