Mon 19 Feb 12:30: Studies with Single Subjects or Large Numbers of Volunteers - Why, & How?
Will will stream ISMRM-23 “Advances in fMRI” Educational Course’s session on Studies with Single Subjects or Large Numbers of Volunteers – Why, & How?” by Wietske van der Zwaag (Spinoza Centre for Neuroimaging, Amsterdam). Let’s watch it together and discuss it afterwards!
Abstract: In the functional MRI field, datasets continue to grow. Interestingly, there are two different trends: There are currently multiple efforts towards collection of datasets with a huge number of participants, to capture the variance in a population, or to use the power of massive averaging to discover subtle brain function patterns. A second trend is towards exhaustive sampling of a single participant (or a few), arguing that measurements of one brain likely generalize to most other brains. Dense sampling allows experiments with either many conditions or extremely detailed images, exploring different types of variance. This talk will discuss both trends.
Venue: MRC CBU Lecture Theatre and Zoom https://us02web.zoom.us/j/82385113580?pwd=RmxIUmphQW9Ud1JBby9nTDQzR0NRdz09
- Speaker: Wietske van der Zwaag (Spinoza Centre for Neuroimaging, Amsterdam)
- Monday 19 February 2024, 12:30-13:30
- Venue: MRC-CBU, 15 Chaucer Road, Cambridge.
- Series: CBU Monday Methods Meeting; organiser: Dace Apšvalka.
Mon 05 Feb 12:30: BOLD & Non-BOLD Contrasts in Human fMRI
Will will stream ISMRM-23 “Advances in fMRI” Educational Course’s session on ”BOLD & Non-BOLD Contrasts in Human fMRI” by Sriranga Kashyap (Krembil Brain Institute, Toronto). Let’s watch it together and discuss it afterwards!
Abstract: FMRI is a non-invasive method that allows scientists to study the brain function during task or at rest. The BOLD contrast is the workhorse of functional neuroimaging. A cascade of physiological events following neuronal activity (changes in blood oxygenation, flow and volume) culminates in the BOLD signal. The versatility of MRI enables imaging of blood flow and volume using techniques such as Arterial Spin Labelling (ASL) and Vascular Space Occupancy (VASO) respectively. In this talk, we will learn about BOLD and non-BOLD contrasts (CBF, CBV ), discuss what they offer and how they differ in their application to human fMRI.
Venue: MRC CBU Lecture Theatre and Zoom https://us02web.zoom.us/j/82385113580?pwd=RmxIUmphQW9Ud1JBby9nTDQzR0NRdz09
- Speaker: Sriranga Kashya (Krembil Brain Institute, Toronto)
- Monday 05 February 2024, 12:30-13:30
- Venue: MRC-CBU, 15 Chaucer Road, Cambridge.
- Series: CBU Monday Methods Meeting; organiser: Dace Apšvalka.
Wed 20 Mar 16:00: Title to be confirmed
Abstract not available
- Speaker: Gordon Brown (University of Warwick)
- Wednesday 20 March 2024, 16:00-17:00
- Venue: Nick Mackintosch Room, Department of Psychology, Downing Site.
- Series: Social Psychology Seminar Series (SPSS); organiser: Yara Kyrychenko.
Mon 11 Mar 11:00: Title to be confirmed NOTE: This talk is on Monday at 11 am !
Abstract not available
NOTE: This talk is on Monday at 11 am !
- Speaker: Eran Halperin (Hebrew University)
- Monday 11 March 2024, 11:00-12:00
- Venue: Ground Floor Lecture Theatre, Department of Psychology, Downing Site, Cambridge.
- Series: Social Psychology Seminar Series (SPSS); organiser: Yara Kyrychenko.
Thu 06 Jun 16:00: Title to be confirmed
Abstract not available
- Speaker: Colleen Deane, University of Southampton
- Thursday 06 June 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 23 May 16:00: Title to be confirmed
Abstract not available
- Speaker: Stefanie Wculek, IRB (Biomedical Research Institute, Barcelona)
- Thursday 23 May 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 09 May 16:00: Title to be confirmed
Abstract not available
- Speaker: Shankar Srinivas, Oxford University
- Thursday 09 May 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 25 Apr 16:00: Title to be confirmed
Abstract not available
- Speaker: Laura Machesky, Department of Biochemistry, University of Cambridge
- Thursday 25 April 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 14 Mar 16:00: Title to be confirmed
Abstract not available
- Speaker: Miguel Torres, Spanish National Center for Cardiovascular Research
- Thursday 14 March 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 14 Mar 16:00: Title to be confirmed
Abstract not available
- Speaker: Miguel Torres, Spanish National Center for Cardiovascular Research
- Thursday 14 March 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 29 Feb 16:00: Title to be confirmed
Abstract not available
- Speaker: Susan Ozanne, MRC, University of Cambridge
- Thursday 29 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 29 Feb 16:00: Title to be confirmed
Abstract not available
- Speaker: Susan Ozanne, MRC, University of Cambridge
- Thursday 29 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Thu 15 Feb 16:00: Towards Human Systems Biology of Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep
The field of human biology faces three major technological challenges. Firstly, the causation problem is difficult to address in humans compared to model animals. Secondly, the complexity problem arises due to the lack of a comprehensive cell atlas for the human body, despite its cellular composition. Lastly, the heterogeneity problem arises from significant variations in both genetic and environmental factors among individuals. To tackle these challenges, we have developed innovative approaches. These include 1) mammalian next-generation genetics, such as Triple CRISPR for knockout (KO) mice and ES mice for knock-in (KI) mice, which enables causation studies without traditional breeding methods; 2) whole-body/brain cell profiling techniques, such as CUBIC , to unravel the complexity of cellular composition; and 3) accurate and user-friendly technologies for measuring sleep and awake states, exemplified by ACCEL , to facilitate the monitoring of fundamental brain states in real-world settings and thus address heterogeneity in human.
By integrating these three technologies, we have made significant progress in addressing two major scientific challenges in sleep research: 1) understanding sleep regulation (sleep mechanisms) and 2) determining the role of sleep (sleep functions). With regard to sleep mechanisms, we have recently proposed the phosphorylation hypothesis of sleep, which emphasizes the role of the sleep-promoting kinase CaMKIIα/CaMKIIβ (Tatsuki et al., 2016; Tone et al., 2022; Ode et al., 2020) and the involvement of calcium signaling pathways (Tatsuki et al., 2016). According to this novel perspective, the dynamics of calcium, representing neural activity during wakefulness, can be integrated and converted into the auto-phosphorylation status of CaMKIIα/CaMKIIβ, which induces and sustains sleep (Tone et al., 2022). Concerning sleep functions, we conducted computational studies to examine synaptic efficacy dynamics during sleep and wakefulness. Our findings led to the formulation of the Wake-Inhibition-Sleep-Enhancement (WISE) hypothesis, suggesting that wakefulness inhibits synaptic efficacy, while sleep enhances it.
During this talk, we will also present our discoveries regarding the identification of muscarinic acetylcholine receptors (Chrm1 and Chrm3) as essential genes of REM sleep. Furthermore, we will discuss new insights into psychiatric disorders, neurodevelopmental disorders, and neurodegenerative disorders derived from the phosphorylation hypothesis of sleep.
- Speaker: Dr Hiroki Ueda, University of Tokyo
- Thursday 15 February 2024, 16:00-17:00
- Venue: Hodgkin Huxley Seminar Room, Physiology builiding, Downing Site CB2 3EG.
- Series: Foster Talks; organiser: er454.
Wed 31 Jan 11:30: Sensory hypersensitivity and poor sleep - understanding neural mechanisms during early development
Poor sleep, sensory hyper-sensitivity and learning delays co-occur in autism (and the general population). In my lab, we aim to delineate causal mechanisms linking these phenotypic trats, in development. I will present findings from an infant sibling study (BASIS) that show early emerging associations between neural measures of sensory processing and infant sleep and new findings from the Snoose study, which uses polysomnography (EEG) to investigate individual variation in how infant sleep adapts to environmental noise.
- Speaker: Teodora Gliga, University of East Anglia
- Wednesday 31 January 2024, 11:30-12:30
- Venue: https://us02web.zoom.us/j/81268825017?pwd=dndNSE9selNDTktIUGNNejZKZDFVUT09 .
- Series: ARClub Talks; organiser: Simon Braschi.
Wed 07 Feb 15:00: Understanding and managing conspiracy beliefs
While considerable progress has been made in uncovering the motivational processes, contextual consequences, and interventions to reduce beliefs in conspiracy theories, certain areas of concern remain unclear. First, recent academic debates have centred around the exact nature of different measures of conspiracy beliefs (e.g., conspiracy mentality vs. belief in specific conspiracy theories). Regardless, what these measures fail to capture are the underlying components that make up a “conspiracist worldview”, alongside the potentially distinct implications of these different ontological processes. To understand this, I discuss our ongoing work on developing a scale that aims to capture a propensity to perceive the world in conspiracist terms. Second, inoculation or “pre-bunking” interventions have proven effective at reducing general misinformation susceptibility and acceptance of conspiracy narratives. However, less is known about the efficacy of these interventions among the specific population of interest; that is, actual “conspiracy theorists”. To explain how interventions might be extended to manage this issue, I will present promising recent evidence from our pre-bunking interventions that are specifically tailored to appeal to those already susceptible to conspiracy narratives. Finally, I will summarise and discuss other potential extensions of pre-bunking interventions to improve their efficacy specifically among “conspiracy theorist” communities.
- Speaker: Mikey Biddlestone (University of Kent)
- Wednesday 07 February 2024, 15:00-16:00
- Venue: Ground Floor Lecture Theatre, Department of Psychology, Downing Site, Cambridge.
- Series: Social Psychology Seminar Series (SPSS); organiser: Yara Kyrychenko.
Thu 01 Feb 12:00: “Complement in Alzheimer’s Disease”
Abstract not available
- Speaker: Dr Wioleta Zelek, Cardiff University
- Thursday 01 February 2024, 12:00-13:00
- Venue: Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.
- Series: Clinical Neurosciences Seminars; organiser: Louise Massara.
Mon 26 Feb 16:15: ANNUAL LECTURE: Saving the Synapse in Development and Alzheimer’s Disease
Abstract not available
- Speaker: Carla Shatz, Stanford University, U.S.A.
- Monday 26 February 2024, 16:15-18:00
- Venue: Physiology Lecture Theatre.
- Series: Adrian Seminars in Neuroscience; organiser: Elisa Galliano.