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Translational Cognitive Neuroscience Lab

 
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A superlist combining individual seminars and series from other lists on talks.cam. These Neuroscience-themed seminars will be advertised throughout the relevant interest group in Cambridge.
Updated: 48 min 49 sec ago

Wed 24 Jan 16:00: New directions in autism early detection, biomarker discovery and understanding heterogeneity using eye tracking and brain imaging

Mon, 22/01/2024 - 10:52
New directions in autism early detection, biomarker discovery and understanding heterogeneity using eye tracking and brain imaging

Social attention, which refers to the specific ability to attend to socially relevant information, is a key aspect of social competency and is significantly impacted in ASD . What a toddler decides to look at, listen to, and shift between are all drivers of early brain development, and foundational for early language and social skills. While difficulties in attending to and reacting to the social world are consistent challenges in ASD , symptoms are heterogenous in nature and degree across individuals. In this lecture, Dr. Pierce will discuss how metrics of social attention as indexed by eye tracking can be powerful tools to: (1) discover diagnostic biomarkers to lower the age of first diagnosis; (2) characterize social attention phenotypes in ASD and understand biological subtypes; (3) reveal prognostic markers to predict future functioning; and (4) suggest possible treatment approaches best matched to each child’s profile. Given that levels of social attention as indexed by eye tracking could be considered a proxy for social attention levels ‘in the real world’, Dr. Pierce will discuss relationships between eye tracking and neural functional levels of activation in brain regions that are critical for social and language development in toddlers with ASD . She will also discuss how bioinformatic tools can be used to reveal key biological subtypes.

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Wed 24 Jan 15:00: The paradox of virality

Mon, 22/01/2024 - 10:41
The paradox of virality

I will present the results from a variety of interconnected studies about intergroup conflict, the spread of (mis)information, and how these topics interact with digital technologies such as social media. First, I will present research showing how social identity motives — particularly out-group negativity — explain why content is widely shared (or goes “viral”) on social media. Then, I will present research showing that widely shared content is often not widely liked — a phenomenon I call the “paradox of virality.” I will discuss the results of a study showing how accuracy and social identity motivations causally shape the belief and spread of (mis)information. I will also present the results of a large-scale digital field experiment that tests the long-term effects of exposure to misinformation and divisive content by having participants unfollow several polarizing social media accounts and misinformation sources for one month. Finally, I will present current and future research directions demonstrating how we can explore these questions on a global scale using multi-site “global studies” and how we can enhance our methods for testing these questions using large-language models.

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Fri 08 Mar 13:00: Controlling the cell cycle

Sun, 21/01/2024 - 21:14
Controlling the cell cycle

Abstract not available

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Fri 01 Mar 13:00: TBA

Sun, 21/01/2024 - 21:13
TBA

Abstract not available

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Fri 09 Feb 13:00: TBA

Sun, 21/01/2024 - 21:11
TBA

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Fri 02 Feb 13:00: TBA

Sun, 21/01/2024 - 21:09
TBA

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Wed 28 Feb 15:00: Title to be confirmed

Sun, 14/01/2024 - 12:37
Title to be confirmed

Abstract not available

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Wed 31 Jan 16:00: Explaining regional mental health prescriptions in England through deprivation and aggregate personality profiles

Sun, 14/01/2024 - 12:33
Explaining regional mental health prescriptions in England through deprivation and aggregate personality profiles

In a given week, one in five adults in England take antidepressants or medication for anxiety. Despite the large variance between regions, there is little understanding of why certain regions have highly elevated prescription levels. We adopted a psycho-social model to investigate spatial prescription patterns by analysing 4.1 billion general, 95 million anxiety-specific, and 178 million depression-specific prescriptions issued in England between 2015 and 2019. We found three possible explanations for why certain regions have highly elevated mental health prescription levels per capita. Areas with elevated levels tended to be: i) smaller ii) be contextually privileged (i.e., short distance to GP); but, more interestingly, iii) affected by high work barriers. By then controlling for these three explanatory variables and matching the prescription data with England’s largest personality survey, we found strong evidence for a potential alternative to mental health drug prescriptions: social activity. Indeed, areas with large proportions of residents scoring high on the extraversion activity facet displayed significantly less anxiety and depression prescriptions. This result offers new evidence and urges the adoption of schemes similar to the social prescribing scheme recently piloted by NHS England in which doctors refer patients to non-medical treatments such as local volunteer groups (e.g., community gardens, community businesses, art and craft centres), reducing both costs and pressure on doctors.

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Wed 14 Feb 15:00: Title to be confirmed

Sun, 14/01/2024 - 12:32
Title to be confirmed

Abstract not available

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Wed 07 Feb 15:00: Title to be confirmed

Sun, 14/01/2024 - 12:26
Title to be confirmed

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Wed 31 Jan 15:00: Title to be confirmed

Sun, 14/01/2024 - 12:24
Title to be confirmed

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Wed 24 Jan 15:00: The paradox of virality

Sun, 14/01/2024 - 12:21
The paradox of virality

Abstract not available

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Thu 01 Feb 12:00: Title to be confirmed

Thu, 11/01/2024 - 14:16
Title to be confirmed

Abstract not available

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Fri 15 Mar 16:00: Molecular insights into GABA-A receptor pharmacology

Tue, 09/01/2024 - 15:36
Molecular insights into GABA-A receptor pharmacology

Dr Paul Miller

University of Cambridge, Department of Pharmacology

Biography

Paul did his PhD and a postdoc with Professor Trevor G Smart at University College London, where he applied electrophysiological and pharmacological approaches to link structure and function for, principally, glycine receptors. Subsequently, from 2010, Paul attained a Wellcome Trust OXION postdoctoral fellowship, in the Division of Structural Biology at University of Oxford, where he established methodologies for the production of membrane proteins within the department. Paul used these techniques to solve structures of GABAA Rs and for the production of antibodies with novel pharmacology and high selectivity. He joined the Department of Pharmacology, University of Cambridge as a lecturer in 2018 to advance antibody pharmacology of ion channels, and has received funding from AMS , BBSRC, Wellcome, Rosetrees Trust, and a range of industry support.

Venue: Level 2 Seminar Room.

Zoom Link: https://cam-ac-uk.zoom.us/j/86321175549?pwd=MnMxTWhub1ViUmhiYWJrSWQ0T25Tdz09

Meeting ID: 863 2117 5549

Passcode: 168608

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Fri 08 Mar 16:00: PDRA Talks: Nuclear envelope integrity in health and disease | A role for the proton

Tue, 09/01/2024 - 15:35
PDRA Talks: Nuclear envelope integrity in health and disease | A role for the proton

Nuclear envelope integrity in health and disease

Dr Anne Janssen

University of Cambridge, Department of Pharmacology

Biography

Anne studied Biotechnology at Wageningen University. After finishing her Masters degree she started her PhD in the lab of Lukas Kapitein (Utrecht University, the Netherlands) working on the generation of inducible tools to study protein aggregation and degradation by the autophagy pathway. During her PhD work she got interested in the nuclear envelope which is why she joined the lab of Delphine Larrieu in 2019 to work on nuclear envelope integrity and premature aging diseases. Initially at CIMR , the lab moved to the department of Pharmacology in 2022. Currently, Anne works on an independent project for which she got a Leverhulme Early Career Fellowship to discover new players in nuclear envelope integrity maintenance.

Dr Luke Pattison

A role for the proton-sensing GPCR , GPR65 in inflammatory joint pain

University of Cambridge, Department of Pharmacology

Biography

Luke studied Molecular and Cellular Biology at the University of Bath. During his undergraduate degree he undertook a placement at the Monash Institute of Pharmaceutical Sciences in Melbourne, Australia, where he studied the compartmentalised signalling of a G protein-coupled receptor (GPCR) implicated in inflammatory pain. Luke undertook his doctoral research in the Smith lab, submitting his thesis in 2021, which explored the contributions of proton-sensing GPC Rs to inflammatory pain. Luke is continuing in the Smith lab as a postdoctoral researcher working on the Advanced Discovery of Visceral Analgesics via Neuroimmune Targets and the Genetics of Extreme human phenotypes (ADVANTAGE) consortium as part of the MRC Advanced Pain Discovery Platform.

Venue: Level 2 Seminar Room

Zoom Link: https://cam-ac-uk.zoom.us/j/89184640892?pwd=VnZXbEU4bDdtbkt5MEV2NWt0RUJtUT09

Meeting ID: 891 8464 0892

Passcode: 620598

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